Obesity-Free Fatty Acids Derived Immune Problem?

In bacterial/viral infected human body, bacteria/viral toxin surface lipo poly saccaride (LPS) generally recognized through a type of receptors called Toll-Like Receptors (TLRs). Especially LPS recognized using TLR-4. Once body recognize the bacterial toxin, it prepares to attack them and creates immunity against it by passing this information to immune cells macrophages. These cells produces cytokines TNF-alpha, IL-6 (a kind of toxic proteins) also leads to activation of NF-kb and JNK1 pathways and inflammatory response. Continuation of this infection leads to severe inflammatory diseases with multiple organ failures.

In western diets prepared using vegetable and animal oils, a plenty available common fatty acids (palmitic/stearic acid) also have good tendency to bind like LPS on Toll-Like Receptor-4 (TLR-4) in humans, this produces similar inflammatory response by cytokine release and activation of NF-kb and JNK1 pathways. Once JNK1 activates, it phosphorylates Insulin Substrate Receptor-1 (IRS-1), which interfere with insulin signaling. Continuation of this Free Fatty Acids (FFAs) activation leads to human whole body inflammation (obesity), insulin resistance/type 2-diabetes and organ failures.